The CD86 antibody (biotin) from MyBioSource.com is a Mouse Monoclonal antibody to CD86. This antibody recognizes Human antigen. The CD86 antibody (biotin) has been validated for the following applications: Flow Cytometry.
Description
The IT2.2 monoclonal antibody reacts with human CD86, an ~80 kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. In addition to CD80, CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152. The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response